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In this study, VDR is essential for the morphogenetic mechanisms that drive hair cycle progression and cell division within the hair follicle. We identify VDR as an https://dcdataroom.com/ important regulator of catagen and show that the phenotype associated with Vdr cKO is a result of diminished apoptosis of epithelial strand cells that are apoptotic in the HF during the catagen stage. The delay in the entry of the HF into the anagen phase leads to alopecia and transforms the HF into a dermal squamous cell composed of epidermal cells.

To study the role of VDR in the regulation of apoptosis catagen, we performed an extensive screen of possible VDR targets by using functional annotation enrichment analysis. In comparison to the control CO fibroblasts, we found 268 genes that are upregulated by the unliganded VDR and downregulated by activation dependent on 1,25D. The majority of these genes were also upregulated by p21 in the WT fibroblasts.

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